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General information Notification Number B/BE/22/V2 Member State to which the notification was sent Belgium Date of acknowledgement from the Member State Competent Authority 05/01/2022 Title of the Project Scientific field evaluation of maize with improved digestibility Proposed period of release: 15/04/2022 to 31/10/2023 Name of the Institute(s) or Company(ies) VIB (Vlaams Interuniversitair Instituut voor Biotechnologie)
Is the same GMPt been notified elsewhere by the same notifier? No Has the same GMPt been notified elsewhere by the same notifier? No Genetically modified plant Complete name of the recipient or parental plant(s):
Common Name Family Name Genus Species Subspecies Cultivar/breeding line
maize poaceae zea zea mays mays
Description of the traits and characteristics which have been introduced or modified, including marker genes and previous modifications: The genetically modified maize plants have an altered composition of their cell wall resulting from the introduction of a mutation in the CCR1 and/or CCR3 genes. These mutations lead to the inactivation of these genes. The plants have up to 20% less lignin in their cell walls which isexpected to contribute to a better digestibility of the maize thereby improving the feed conversion rate Genetic modification Type of genetic modification: Other; Other

Targeted editing of genes using CRISPR-Cas.
Brief description of the method used for the genetic modification: The plants have been modified using CRISPR-Cas. The CRISPR-Cas machinery was introduced into the maize using Agrobacterium tumefaciens mediated genetic modification. This resulted in the stable integration of T-DNA containing the sequences coding for the guide RNA and CAS protein into the genome of the maize. Plants with the desired edit were selected and the T-DNA was segregated out in the next generations leading to the selection of plants that only contained the desired edit but no longer contained any foreign genetic material If the recipient or parental plant is a forest tree species, describe ways and extent of dissemination and specific factors affecting dissemination: Not applicable Experimental Release Purpose of the release: The purpose of the release is to measure the performance of the modified maize plants under normal field conditions and learn whether they also in these conditions have an altered composition of their cell wall. The field trial also has the goal to determine whether the modification would lead to undesired effects such as a higher vulnerability for breaking of their stem during strong winds. Geographical location of the site: The field trial will take place on grounds belonging to the ILVO research institute in the municipality of Wetteren. Size of the site (m2): The trial plot, including non-modified controls, non-modified fertilizer lines and non-modified buffer rows is 684 m2. Relevant data regarding previous releases carried out with the same GM-plant, if any, specifically related to the potential environmental and human health impacts from the release: The lines have not been field tested before. Environmental Impact and Risk Management Summary of the potential environmental impact from the release of the GMPts: The environmental impact from the release is expected to be zero. The modified characteristics are not expected to lead to greater weediness or the ability of the maize to establish in non-agricultural habitats. The modified characteristics are also not expected to change the interaction of the maize with herbivores. It is possible that the altered composition of the cell wall leads to a change in the variety of micro-organisms that live in the maize, but this is not seen as a negative impact.There will also be no spread of the modified maize to the environment. The male flowers (tassels) of the maize will be removed before they can start shedding pollen, meaning that shedding of modified pollen to the environment is impossible. Also the spread of seeds to the environment is prevented. The modified seeds are well retained in the cobs and all cobs will be carefully hand harvested to prevent any spread of seeds. Brief description of any measures taken for the management of risks: The risk of spread of the modified properties to the environment is mitigated by removing the tassel, thus preventing the spread of modified pollen to non-modified maize plants in the surroundings. The formed modified seeds are, as already stated above, well retained in the cobs and these cobs will be very carefully hand harvested, thus preventing any spread of seeds to the environment. Experience with such field trials in the past 8 years has shown that the way the cobs are harvested effectively prevents any volunteers being formed. The field trial plot is surrounded by a 1.80 m high wire fence to prevent accidental trespassing and accidental removal or spread of GM material. Summary of foreseen field trial studies focused to gain new data on environmental and human health impact from the release: There are no specific studies foreseen to gain new data on the environmental and human health impact from the release other than the study of the phenotype and growth characteristics of the maize. Final report - European Commission administrative Information Consent given by the Member State Competent Authority: Yes
04/20/2022
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