Nanotechnology / Projects

Second Programme of Community action in the Field of Health 2008-2013
Safety evaluation of manufactured nanomaterials by characterisation of their potential genotoxic hazard [NANOGENOTOX]
Human exposure to manufactured nanomaterials (MNs) used in consumer products may occur during several phases of their life cycle. The lack of scientific knowledge makes regulation difficult.

The aim ...
Human exposure to manufactured nanomaterials (MNs) used in consumer products may occur during several phases of their life cycle. The lack of scientific knowledge makes regulation difficult.

The aim of the Joint Action is to establish a robust methodology to assess the potential genotoxicity of MNs and to generate data on the genotoxic effect of certain reference materials (www.nanogenotox.eu).

The JA specific objectives are:
To obtain detailed physicochemical properties for each selected MN
To determine the influence of exposure media on MNs dispersability and to identify the optimum preparation protocols for the specific MNs
To generate in vitro genotoxicity data on MNs
To perform a round robin test on in vitro genotoxicity testing of MNs
To determine relevant doses and sampling time for biodistribution and in vivo genotoxicity studies, and to identify MN accumulation in organs for in vivo genotoxicity tests
To generate data from in vivo genotoxicity selected tests, and to assess the correlation between in vivo and in vitro results taking into account the kinetic results
Start date: 01/03/2010 - End date: 01/03/2013

Call: Improve Citizen''S Health Security (Hs-2009)
Topic: Nanotechnology